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Pituitary and Stalk Lesions (Infundibulo-Hypophysitis) Associated with Immunoglobulin G4-related Systemic Disease: an Emerging Clinical Entity Endo J 56:1033-1041, Shimatsu, A.,et al, 2009 See this aricle in Pubmed Article Abstract Inflammatory lesions of the pituitary gland are rarely encountered. Recently, the concept of immunoglobulin G4 (IgG4)-related systemic disease was proposed in Japan, and more than 20 cases have been reported as possibly associated with infundibulo-hypophysitis since 2000. We herein review such case reports in the published literature and in the abstracts of scientific meetings. Almost all cases involved middle-aged to elderly men presenting with various degrees of hypopituitarism and diabetes insipidus and demonstrating a thickened pituitary stalk and/or pituitary mass.

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